The following list the scientific publications by Solenic’s Clinical, Research, and Development teams showcasing the company’s dedication to rigorous scientific study and development. These research efforts provide compelling evidence for the potential of AMF technology to improve patient outcomes impacted by peri-prosthetic joint infections (PJIs).
M. Hairgrove et al., “Alternating magnetic fields enhance anti-biofilm activity across pathogen and antibiotic space,” Scientific Reports, 16, Article number: 1837 (2026) https://www.nature.com/articles/s41598-025-31574-1
I. A. Somawardana et al., “Alternating Magnetic Fields (AMF) and Linezolid Reduce Staphylococcus aureus Biofilm in a Large Animal Implant Model,” Journal of Infection, vol. 0, no. 0, p. 106271, Sep. 2024, doi: 10.1016/J.JINF.2024.106271. https://www.journalofinfection.com/article/S0163-4453(24)00205-6/fulltext
Shaikh et al., “Intermittent alternating magnetic fields diminish metal-associated biofilm in vivo,” Sci Rep, vol. 13, no. 1, Dec. 2023, doi: 10.1038/s41598-023-49660-7. https://www.nature.com/articles/s41598-023-49660-7
Prasad et al., “Quantifying the relationship between biofilm reduction and thermal tissue damage on metal implants exposed to alternating magnetic fields,” International Journal of Hyperthermia, vol. 39, no. 1, pp. 713–724, Sep. 2022, doi: 10.1080/02656736.2022.2065038. https://www.tandfonline.com/doi/full/10.1080/02656736.2022.2065038
V. Sadaphal, “Engineering consideration for the treatment of prosthetic joint infections using alternating magnetic fields (AMF),” UT Southwestern Graduate School of Biomedical Sciences collection. https://utswmed-ir.tdl.org/items/302ae60f-2b19-491e-beac-ae2c71ba690f
Wang et al., “Alternating magnetic fields and antibiotics eradicate biofilm on metal in a synergistic fashion,” NPJ Biofilms Microbiomes, vol. 7, no. 1, Sep. 2021, doi: 10.1038/s41522-021-00239-y. https://www.nature.com/articles/s41522-021-00239-y
Munaweera et al., “Temperature-sensitive liposomal ciprofloxacin for the treatment of biofilm on infected metal implants using alternating magnetic fields,” International Journal of Hyperthermia, vol. 34, no. 2, 2018, doi: 10.1080/02656736.2017.1422028. https://www.tandfonline.com/doi/full/10.1080/02656736.2017.1422028
Wang, J. Vachon, C. A. Pybus, S. Shaikh, R. Chopra, and D. E. Greenberg, “315. Alternating Magnetic Fields (AMF) and Antibiotics Eradicate Biofilm on Metal in a Synergistic Fashion,” Open Forum Infect Dis, vol. 7, no. Supplement_1, 2020, doi: 10.1093/ofid/ofaa439.511.
A. Ciarolla, N. Lapin, D. Williams, R. Chopra, and D. E. Greenberg, “Physical Approaches to Prevent and Treat Bacterial Biofilm.,” Antibiotics (Basel), vol. 12, no. 1, Dec. 2022, doi: 10.3390/antibiotics12010054. https://www.mdpi.com/2079-6382/12/1/54
Sadaphal et al., “Feasibility of heating metal implants with alternating magnetic fields (AMF) in scaled up models,” International Journal of Hyperthermia, vol. 39, no. 1, pp. 81–96, 2022, doi: 10.1080/02656736.2021.2011434. https://www.tandfonline.com/doi/full/10.1080/02656736.2021.2011434
Cheng et al., “Remote acoustic sensing as a safety mechanism during exposure of metal implants to alternating magnetic fields,” PLoS One, vol. 13, no. 5, 2018, doi: 10.1371/journal.pone.0197380. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197380
S. Shaikh et al., “335. Using high temperatures to eradicate prosthetic joint associated biofilms on metal implants using alternating magnetic field: Efficacy and safety implications,” Open Forum Infect Dis, vol. 7, no. Supplement_1, 2020, doi: 10.1093/ofid/ofaa439.531. https://academic.oup.com/ofid/article/7/Supplement_1/S238/6058555
Chopra et al., “Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections,” Sci Rep, vol. 7, no. 1, 2017, doi: 10.1038/s41598-017-07321-6. https://www.nature.com/articles/s41598-017-07321-6